What is Lamictal (Lamotrigine)?





Lamictal is an anticonvulsant drug used in the treatment of bipolar, epilepsy and off-label for depression. Lamictal is a member of the sodium channel blocking class of antiepileptic drugs and decreases Glutamate release, although it is chemically unrelated to other anticonvulsants.

There are many side effects associated with Lamictal and the prescribing information includes a black box warning about life-threatening skin reactions. Patients are warned to seek immediate medical treatment for any unexpected skin rash, as it may be an indication of a possible serious or even deadly side effect called toxic epidermal necrolysis.  Additionally, Lamictal binds to melanin-containing (pigment) tissues such as the iris of the eye. Long-term consequences of this are unknown at this time. Approximately 7% of patients experience insomnia from Lamictal.  

Due to the risk of seizure and other serious withdrawal symptoms, it is important to withdraw Lamictal slowly.

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Lamictal Withdrawal Symptoms May Include:




Irritability, seizures, rage, feelings of hostility, brain zaps, loss of focus, confusion, lethargy, exhaustion, migraines or severe headaches, vivid nightmares, tremors, jumpy muscles, fear, dizziness, anxiety, racing and irrational thoughts, suicidal thoughts, insomnia, feelings of worthlessness, depression, getting lost even in familiar places.

Lamictal Side Effects May Include:

    Headaches, insomnia, flu syndrome, fever, neck pain, migraine, nausea, flatulence, weight gain, edema, dizziness, anorexia, dry mouth, rectal hemorrhage, joint and muscle pain, peptic ulcer, peripheral edema, amnesia, ataxia, depression, epidermal necrolysis , hyperaesthesia (abnormal increase in sensitivity to stimuli), libido increase, decreased or increased reflexes, irritability, suicidal ideation, nystagmus (involuntary eye movements), bronchitis, espistaxis (bleeding from the nose), dyspnea (shortness of breath), contact dermatitis, dry skin, sweating, vision abnormality.

    Disclaimer: *Because prescription medications can cause severe withdrawal reactions, do not stop taking any medication without first consulting your physician. The decision to taper any medication should be discussed with your doctor and done with their consent and support. More...